Structural signature of sporadic Creutzfeldt–Jakob disease
نویسندگان
چکیده
منابع مشابه
Somatic signature of brain-specific single nucleotide variations in sporadic Alzheimer's disease.
BACKGROUND Although genome-wide association studies have shown that genetic factors increase the risk of suffering late-onset, sporadic Alzheimer's disease (SAD), the molecular mechanisms responsible remain largely unknown. OBJECTIVE The aim of the study was to investigate the presence of somatic, brain-specific single nucleotide variations (SNV) in the hippocampus of SAD samples. METHODS B...
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Point mutations in the amyloid-β (Aβ) coding region produce a combination of mutant and WT Aβ isoforms that yield unique clinicopathologies in familial Alzheimer's disease (fAD) and cerebral amyloid angiopathy (fCAA) patients. Here, we report a method to investigate the structural variability of amyloid deposits found in fAD, fCAA, and sporadic AD (sAD). Using this approach, we demonstrate that...
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ژورنال
عنوان ژورنال: European Journal of Neurology
سال: 2019
ISSN: 1351-5101,1468-1331
DOI: 10.1111/ene.13930